Gender Differences in Cancer-associated Venous Thromboembolism

Title:Gender Differences in Cancer-associated Venous Thromboembolism

Volume: 24 Issue: 24

Author(s): Silvia Riondino, Fiorella Guadagni, Vincenzo Formica, Patrizia Ferroni and Mario Roselli*

Affiliation:

• Department of Systems Medicine, Faculty of Medicine, University of Rome Tor Vergata, Via di Montpellier 1, Rome,Italy

Keywords: Venous thromboembolism, cancer, gender, VTE occurrence, VTE recurrence, thromboprophylaxis.

Abstract: Venous thromboembolism (VTE) is a commonly diagnosed multifactorial condition with significant morbidity and mortality, occurring in up to 20% of cancer patients. Indeed, patients with cancer are in a higher pro-thrombotic state due to alterations in their haemostatic- coagulative system, stasis and blood flow slowdown, endothelial dysfunction, vascular inflammation and platelet activation. Moreover, several cancer-dependent factors can sum up to trigger a first episode of VTE or to cause its recurrence in the course of anticoagulant treatment. Such a pro-thrombotic condition is further worsened by additional favoring risks such as immobilization, infection, surgery, or insertion of a central venous catheter, and anti-cancer therapy. Furthermore, in the secondary prevention setting, the anticoagulant therapy is accompanied by a high incidence of bleeding complications. Given the above, understanding and identifying the factors associated with the incidence and clinical outcome of VTE in cancer patients might be of great value in the prevention and management of VTEattributable complications, including death. Differences associated to gender on cancerrelated VTEs are not yet fully defined; many of the studies that addressed the question have been biased by erroneous/non homogeneous inclusion criteria. In the present review, we analyzed the potential differences in VTEs occurrence in cancer patients, by reporting the most significant findings in the recent literature. The identification of a differential clinical approach according to patient sex, might prompt the design of personalized treatment options tailored and optimized according to algorithms for oncological VTE prevention.

Cite this article as:

Riondino Silvia, Guadagni Fiorella, Formica Vincenzo, Ferroni Patrizia and Roselli Mario*, Gender Differences in Cancer-associated Venous Thromboembolism, Current Medicinal Chemistry 2017; 24 (24) . https://dx.doi.org/10.2174/0929867323666161018144505