性别对生物标志物的影响，药效学和药代动力学

Title:Sex Impact on Biomarkers, Pharmacokinetics and Pharmacodynamics

Volume: 24 Issue: 24

关键词: 性别差异，药代动力学，药效学，生物标志物，阿片样物质，怀孕。

摘要: Sex is one of several factors influencing pharmacological responses, but research on its effects on pharmacokinetics and pharmacodynamics, although emerging remarkably, remains poor and contains many methodological issues. In this review, the current state of knowledge about sex differences in pharmacokinetics and some hints to pharmacogenomics were evaluated. Moreover, considering that many pharmacological responses are monitored through biomarkers, the influence of sex on some biomarkers has been reported. Finally, we report sex differences in pharmacodynamics, particularly analysing opioids and their use during pregnancy, labor and breastfeeding. In conclusion, a more precise sex- and genderbased approach appears necessary to achieve more evidence-based therapy in men and women.

Cite this article as:

Sex Impact on Biomarkers, Pharmacokinetics and Pharmacodynamics, Current Medicinal Chemistry 2017; 24 (24) . https://dx.doi.org/10.2174/0929867323666161003124616