Development of Encapsulated Self Healed Microparticles: Evaluation by RSM

Title:Development of Encapsulated Self Healed Microparticles: Evaluation by RSM

Volume: 8 Issue: 1

Author(s): Sunil Yadava, Jitendra Naik, Jayesh Patil and Vinod Mokale

Affiliation:

Keywords: Ciprofloxacin, encapsulation, hydrophilic drug, kinetics, RSM, self healed microparticles.

Abstract: Background: Present work deals with the development of a hydrophilic drug encapsulated self healed microparticles.

Objective: To develop encapsulated microparticles of Ciprofloxacin, model hydrophilic drug.

Method: A modified o/o/w multi emulsion solvent evaporation method was used for the development of Ciprofloxacin encapsulated microparticles. Aluminium hydroxide was used as a healing agent. This method produced encapsulated carrier for hydrophilic drug and sustained release system. Microparticles were evaluated by using 3-level factorial design.

Results: The obtained encapsulated microparticles were characterized by FTIR, FESEM and elemental analysis. The variables such as plymer (X₁) and aluminium hydroxide (X₂) were optimized for the maximum encapsulation efficiency (Y₁) and the optimum drug release (Y₂₎ with the help of the response surface methodology (RSM). The RSM predicted that, both X₁ and X₂ were significant for the Y₁ (pvalues- 0.0006 & 0.0023) and Y₂ (p- values-0.0003 & <0.0001). An increase in the concentrations of the polymer and aluminium hydroxide increased Y₁ and decreased Y₂. The obtained optimum value of Y₁ and Y₂ were 80.86 and 55.34, respectively. Those were well in agreement with the predicted value by RSM. In- vitro drug release study was also performed and data were checked for various kinetic models to confirm the sustained release behaviour of the microparticles.

Conclusion: The results showed that concentration of ethylcellulose and aluminium hydroxide greatly influenced the % encapsulation efficiency and drug release. The absence of drug polymer interactions was confirmed by FTIR spectroscopy. In-vitro drug release analysis and its kinetic modelling confirmed the sustained release behaviour of the microparticles.

Cite this article as:

Yadava Sunil, Naik Jitendra, Patil Jayesh and Mokale Vinod, Development of Encapsulated Self Healed Microparticles: Evaluation by RSM, Micro and Nanosystems 2016; 8 (1) . https://dx.doi.org/10.2174/1876402908666160906113943

DOI https://dx.doi.org/10.2174/1876402908666160906113943	Print ISSN 1876-4029
Publisher Name Bentham Science Publisher	Online ISSN 1876-4037