Micro-Encapsulation of Antibiotic in Cellulose Nanoparticle Inhibits Bacteria

Title:Micro-Encapsulation of Antibiotic in Cellulose Nanoparticle Inhibits Bacteria

Volume: 8 Issue: 1

Author(s): Subash C.B. Gopinath, Chong S. Goh, Marimuthu Citartan, Thangavel Lakshmipriya, Mohd K.M. Arshad, Fatin N.M. Faudzi, Ruslinda A. Rahim, Uda Hashim, Suresh V. Chinni and Thean-Hock Tang

Affiliation:

Keywords: Antibiotic, cellulose nanoparticle, encapsulation, escherichia coli, inhibition, pH.

Abstract: Background: Nanoparticles have been considered for a wide range of applications both in soluble and insoluble forms. We take an advantage of soluble form of cellulose nanoparticle (CNP) for encapsulation of antibiotic/drug.

Methods: The CNP was prepared by micro-emulsion method using organic and oil as the continuous phase and tween-80 as the emulsifying agent.

Results: Formation of uniform-sized CNPs was evidenced by scanning and atomic force microscopic studies, measured as the average size of }50 nm. CNP prepared under acidic and neutral conditions did not show improvement for the inhibition of Escherichia coli growth. However, when CNP was alkalinized, it yielded higher antibiotic loading and showed greater rate of bactericidal effect with 3 folds higher efficiency. Increase in the amount of cellulose did not increase the encapsulation rate.

Conclusion: This study demonstrates the application antibiotic encapsulated CNP for microbial inhibi- tion and highly applicable for drug delivery system.

Cite this article as:

Gopinath C.B. Subash, Goh S. Chong, Citartan Marimuthu, Lakshmipriya Thangavel, Arshad K.M. Mohd, Faudzi N.M. Fatin, Rahim A. Ruslinda, Hashim Uda, Chinni V. Suresh and Tang Thean-Hock, Micro-Encapsulation of Antibiotic in Cellulose Nanoparticle Inhibits Bacteria, Micro and Nanosystems 2016; 8 (1) . https://dx.doi.org/10.2174/1876402908666160720104019

DOI https://dx.doi.org/10.2174/1876402908666160720104019	Print ISSN 1876-4029
Publisher Name Bentham Science Publisher	Online ISSN 1876-4037