Abstract
Lactonamycin is a natural antibiotic that exhibits potent antimicrobial and anticancer activities. It has a unique hexacyclic aglycone core (lactonamycinone) that features with a naphtho[e]isoindole moiety incorporating a densely oxygenated fused perhydrofuran-furanone ring with a labile tertiary methoxy moiety, and a 2-deoxy sugar unit attached by a tertiary -ketoglycosidic bond. The intriguing structure of the lactonamycin and the urgent need for novel effective antibiotics against resistant bacterial infections have stimulated considerable efforts towards the total synthesis of lactonamycin and its analogs. This paper summarizes the recent progresses towards the total synthesis of lactonamycin and its analogs, including the construction of the AB, ABCD, ABCDE, EF, CDEF, BCDEF ring systems, and the aglycone core.
Keywords: Antibiotics, antimicrobial, lactonamycin, lactonamycin Z, total synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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