Brain: The Potential Diagnostic and Therapeutic Target for Glaucoma

Title:Brain: The Potential Diagnostic and Therapeutic Target for Glaucoma

Volume: 15 Issue: 7

Author(s): Muneeb A. Faiq, Rima Dada, Ashutosh Kumar, Daman Saluja and Tanuj Dada

Affiliation:

Keywords: Brain, glaucoma, lateral geniculate nucleus, optic nerve, retinal ganglion cell, visual cortex.

Abstract: Glaucoma is a form of multifactorial ocular neurodegeneration with immensely complex etiology, pathogenesis and pathology. Though the mainstream therapeutic management of glaucoma is lowering of intraocular pressure, there is, as of now, no cure for the disease. New evidences ardently suggest brain involvement in all aspects of this malady. This consequently advocates the opinion that brain should be the spotlight of glaucoma research and may form the impending and promising target for glaucoma diagnosis and treatment. The present analysis endeavors at understanding glaucoma vis-à-vis brain structural and/or functional derangement and central nervous system (CNS) degeneration. Commencing with the premise of developing some understanding about the brain-nature of ocular structures; we discuss the nature of the cellular and molecular moieties involved in glaucoma and Alzheimer’s disease. Substantial deal of literature implies that glaucoma may well be a disease of the brain, nevertheless, manifesting as progressive loss of vision. If that is the case, then targeting brain will be far more imperative in glaucoma therapeutics than any other remedial regimen currently being endorsed.

Cite this article as:

Faiq A. Muneeb, Dada Rima, Kumar Ashutosh, Saluja Daman and Dada Tanuj, Brain: The Potential Diagnostic and Therapeutic Target for Glaucoma, CNS & Neurological Disorders - Drug Targets 2016; 15 (7) . https://dx.doi.org/10.2174/1871527315666160321111522