Abstract
In this review we chose to concentrate on the bibliography data from 2013 to 2015 (until February), related to the application of the Inverse Electron Demand Diels-Alder (IEDDA) reaction to the synthesis of heterocycles, as building blocks for natural products synthesis.
Moreover, the application of the IEDDA reaction to the recently developed bioorthogonal ligations (in 2008), using tetrazines moieties as the diene partners, and engineered alkenes or alkynes as dienophiles, will be detailed. The in vivo applications of the bioorthogonal ligations are particularly amazing and undoubtedly demonstrate the usefulness of this chemistry.
Keywords: IEDDA, Diels-Alder, heterocycles, bioorthogonal ligation, tetrazine, cyclooctyne, strained alkenes.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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