Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications

Title:Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications

Volume: 22 Issue: 5

Author(s): Rafia Mir, Sajjad Karim, Mohammad Amjad Kamal, Cornelia M. Wilson and Zeenat Mirza

Affiliation:

Keywords: Conotoxins, classification, structure, drugs.

Abstract: Cone snails, also known as marine gastropods, from Conus genus produce in their venom a diverse range of small pharmacologically active structured peptides called conotoxins. The cone snail venoms are widely unexplored arsenal of toxins with therapeutic and pharmacological potential, making them a treasure trove of ligands and peptidic drug leads. Conotoxins are small disulfide bonded peptides, which act as remarkable selective inhibitors and modulators of ion channels (calcium, sodium, potassium), nicotinic acetylcholine receptors, noradrenaline transporters, N-methyl-D-aspartate receptors, and neurotensin receptors. They are highly potent and specific against several neuronal targets making them valuable as research tools, drug leads and even therapeutics. In this review, we discuss their gene superfamily classification, nomenclature, post-translational modification, structural framework, pharmacology and medical applications of the active conopeptides. We aim to give an overview of their structure and therapeutic potential. Understanding these aspects of conopeptides will help in designing more specific peptidic analogues.

Cite this article as:

Mir Rafia, Karim Sajjad, Kamal Amjad Mohammad, Wilson M. Cornelia and Mirza Zeenat, Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications, Current Pharmaceutical Design 2016; 22 (5) . https://dx.doi.org/10.2174/1381612822666151124234715