Dendritic Cell Endothelium Interaction in Autoimmunity

Title: Dendritic Cell Endothelium Interaction in Autoimmunity

Volume: 10 Issue: 2

Author(s): C. L. Schlichting, W. D. Schareck and M. Weis

Affiliation:

Keywords: autoimmunity, dendritic cells, endothelium, endothelial cell, migration, inflammation

Abstract: Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.

Cite this article as:

Schlichting L. C., Schareck D. W. and Weis M., Dendritic Cell Endothelium Interaction in Autoimmunity, Current Pharmaceutical Design 2004; 10 (2) . https://dx.doi.org/10.2174/1381612043453397