Contribution of Nanotechnology to Improved Treatment of Periodontal Disease

Title:Contribution of Nanotechnology to Improved Treatment of Periodontal Disease

Volume: 21 Issue: 22

Author(s): Spela Zupancic, Petra Kocbek, Sasa Baumgartner and Julijana Kristl

Affiliation:

Keywords: Biofilm, drug delivery, liposomes, nanomedicine, nanofibers, nanoparticles, periodontal regeneration, periodontitis.

Abstract: Periodontal disease is chronic inflammation of periodontal tissues resulting in formation of periodontal pockets, periodontal attachment loss and progressive destruction of the ligament and alveolar bone. This review gives an update on periodontal disease pathogenesis, which is important for the development of novel methods and delivery systems for its treatment. The available treatment approaches, including removal of dental plaque, modulation of the host inflammatory response, and regeneration of periodontal tissue, are reviewed and their drawbacks discussed. Furthermore the latest achievements involving development of nanomedicines, which represent a new approach to better treatment of periodontal disease, are highlighted. They enable local drug delivery to particular tissues, cells, or subcellular compartments in periodontal pockets, either to biofilm pathogens or host cells, as well as control the release of incorporated drugs, usually antibiotic or anti-inflammatory. Specific examples of the nanocarriers or nanomaterials such as liposomes, lipid and polymeric nanoparticles, nanocrystals, dendrimers, and nanofibers under development for the treatment of periodontal disease are also clearly reviewed. Nanofibers are of special interest as nanodelivery systems and scaffolds for the regeneration of periodontal tissue. Finally, the future outlook of novel therapeutic approaches involving nanodelivery systems in the treatment of periodontal disease is provided.

Cite this article as:

Zupancic Spela, Kocbek Petra, Baumgartner Sasa and Kristl Julijana, Contribution of Nanotechnology to Improved Treatment of Periodontal Disease, Current Pharmaceutical Design 2015; 21 (22) . https://dx.doi.org/10.2174/1381612821666150531171829