New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid

Title:New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid

Volume: 22 Issue: 8

Author(s): Adriano Mollica, Roberto Costante, Azzurra Stefanucci and Ettore Novellino

Affiliation:

Keywords: Asymmetric synthesis, building blocks, domoic acid, kainic acid, proline chimeras.

Abstract: Mono or di-substituted prolines, namely proline chimeras of natural or synthetic origin, carry the side chain of other specific amino acids on the pyrrolidine ring. Thus, proline chimeras are useful tools for a wide range of chemical and biological applications as chiral synthons or building blocks for peptidomimetic design. We focused our attention on domoic acid and kainic acid and we report here a concise and up to date review on their stereoselective and asymmetric syntheses.

Cite this article as:

Mollica Adriano, Costante Roberto, Stefanucci Azzurra and Novellino Ettore, New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid, Protein & Peptide Letters 2015; 22 (8) . https://dx.doi.org/10.2174/0929866522666150206170716

DOI https://dx.doi.org/10.2174/0929866522666150206170716	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305