Commentary: The Effects of Psychological Stress on Microglial Cells in the Brain

Title:Commentary: The Effects of Psychological Stress on Microglial Cells in the Brain

Volume: 14 Issue: 3

Author(s): Ti-Fei Yuan, Gonglin Hou, Ying Zhao and Oscar Arias-Carrion

Affiliation:

Keywords: Antidepressant, glucocorticoid, microglia, norepinephrine, stress.

Abstract: Psychological stress leads to activation and proliferation of microglial cells in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators underlying anti-depression therapies.

Cite this article as:

Yuan Ti-Fei, Hou Gonglin, Zhao Ying and Arias-Carrion Oscar, Commentary: The Effects of Psychological Stress on Microglial Cells in the Brain, CNS & Neurological Disorders - Drug Targets 2015; 14 (3) . https://dx.doi.org/10.2174/1871527314666150123122851