The Functions of F-box Proteins in Regulating the Epithelial to Mesenchymal Transition

Title:The Functions of F-box Proteins in Regulating the Epithelial to Mesenchymal Transition

Volume: 21 Issue: 10

Author(s): Jingna Su, Xuyuan Yin, Xiuxia Zhou, Wenyi Wei and Zhiwei Wang

Affiliation:

Keywords: Cancer, degradation, E3 ligases, EMT, ubiquitin.

Abstract: Epithelial to mesenchymal transition (EMT) has been unraveled to regulate the tumor invasion and metastasis processes. In this review, in order to better understand the regulatory mechanisms of EMT, we describe that F-box pr oteins could be critically involved in regulating the EMT process in human cancers. Specifically, we discuss how th ese F-box proteins directly control the stability of EMT regulators such as E-cadherin, β-catenin, Twist, Slug, Snail and ZEB. Moreover, we summary mechanistically how the F-box proteins govern EMT progression through regulation of EMT inducers including Notch, NF-κB, Akt, Hedgehog, mTOR, and HIF-1α. Therefore, targeting these F-box proteins could be useful for treating human cancers.

Cite this article as:

Su Jingna, Yin Xuyuan, Zhou Xiuxia, Wei Wenyi and Wang Zhiwei, The Functions of F-box Proteins in Regulating the Epithelial to Mesenchymal Transition, Current Pharmaceutical Design 2015; 21 (10) . https://dx.doi.org/10.2174/1381612821666141211144203