Amyotrophic Lateral Sclerosis: A Genetic Point of View

Title:Amyotrophic Lateral Sclerosis: A Genetic Point of View

Volume: 14 Issue: 8

Author(s): C. Carlesi, E. Caldarazzo Ienco, M. Mancuso and G. Siciliano

Affiliation:

Keywords: Amyotrophic Lateral Sclerosis, dementia, genetic tests, GWA, mutation, phenotype, WES.

Abstract: In the last twenty years the rapid advances in neurogenetic have revolutionized not only the molecular, pathological, inheritance but also the clinical concept of ALS.

Here we review the current genetic breakthrough in familial and sporadic ALS, considering how this knowledge has allowed widening of the scenario on the possible pathogenic disease mechanisms and better understanding of the relationship between the genetic, pathological and clinical subtypes.

Cite this article as:

Carlesi C., Ienco Caldarazzo E., Mancuso M. and Siciliano G., Amyotrophic Lateral Sclerosis: A Genetic Point of View, Current Molecular Medicine 2014; 14 (8) . https://dx.doi.org/10.2174/1566524014666141010155822