Abstract
Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach.
Keywords: CADASIL, Fabry disease, ischemia, MELAS, stroke.
Current Molecular Medicine
Title:Common Genetic Conditions of Ischemic Stroke to Keep in Mind
Volume: 14 Issue: 8
Author(s): M. Mancuso, D. Orsucci, E. Caldarazzo Ienco, M. Brondi, C. Simoncini, A. Chiti, V. Montano, E. Terni, N. Giannini, G. Siciliano and U. Bonuccelli
Affiliation:
Keywords: CADASIL, Fabry disease, ischemia, MELAS, stroke.
Abstract: Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach.
Export Options
About this article
Cite this article as:
Mancuso M., Orsucci D., Ienco Caldarazzo E., Brondi M., Simoncini C., Chiti A., Montano V., Terni E., Giannini N., Siciliano G. and Bonuccelli U., Common Genetic Conditions of Ischemic Stroke to Keep in Mind, Current Molecular Medicine 2014; 14 (8) . https://dx.doi.org/10.2174/1566524014666141010132258
DOI https://dx.doi.org/10.2174/1566524014666141010132258 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine
Current Stem Cell Research & Therapy Somatic Genome Variations in Health and Disease
Current Genomics Obstructive Sleep Apnea Syndrome: From Phenotype to Genetic Basis
Current Genomics Developments in Non-Surgical Therapies for Abdominal Aortic Aneurysm
Current Vascular Pharmacology Molecular Basis of Young Ischemic Stroke
Current Medicinal Chemistry Drug Repositioning: A Unique Approach to Refurbish Drug Discovery
Current Drug Discovery Technologies Arrhythmias and Left Ventricular Hypertrabeculation/Noncompaction
Current Pharmaceutical Design Role of Azoles in Cancer Prevention and Treatment: Present and Future Perspectives
Anti-Cancer Agents in Medicinal Chemistry Notch Signaling in Cardiovascular Disease and Calcification
Current Cardiology Reviews Repair of Dilated Aortic Root and Sinotubular Junction Using a Stabilizer Ring
Recent Patents on Cardiovascular Drug Discovery Redox Control of Cardiovascular Homeostasis by Angiotensin II
Current Pharmaceutical Design Volume Measurement in the Diagnosis of Mounier Kuhn Syndrome and an Unknown Accompanying Pathology: Pulmonary Artery Enlargement
Current Medical Imaging Pharmacotherapy of Abdominal Aortic Aneurysms
Current Vascular Pharmacology Intracranial Non-traumatic Aneurysms in Children and Adolescents
Current Pediatric Reviews The Multiple Aspects of Stroke and Stem Cell Therapy
Current Molecular Medicine Antibody Targeting of TGF-β in Cancer Patients
Current Pharmaceutical Biotechnology Infection, Infectious Agents and Vascular Disease
Reviews on Recent Clinical Trials Novel Inflammatory Indices in Aortic Disease
Current Medicinal Chemistry Treatment of Choroidal Neovascularization in High Myopia
Current Drug Targets Transforming Growth Factor β Signaling Perturbation in the Loeys-Dietz Syndrome
Current Medicinal Chemistry