Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure

Title:Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure

Volume: 20 Issue: 40

Author(s): Konstantinos Tziomalos, Asterios Karagiannis and Vasilios G. Athyros

Affiliation:

Keywords: Statins, fibrates, ezetimibe, colesevelam, nicotinic acid, C-reactive protein, fibrinogen, blood pressure, pleiotropic effects.

Abstract: In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways. We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation, thrombosis or blood pressure play a role in their antiatherogenic potential.

Cite this article as:

Tziomalos Konstantinos, Karagiannis Asterios and Athyros G. Vasilios, Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure, Current Pharmaceutical Design 2014; 20 (40) . https://dx.doi.org/10.2174/1381612820666140622201452