Trifluoromethylated Heterocycles

Title:Trifluoromethylated Heterocycles

Volume: 14 Issue: 7

Author(s): Andrei A. Gakh and Yuriy Shermolovich

Affiliation:

Keywords: Trifluoromethyl group, heterocycles.

Abstract: This review is a follow-up to the previous chapter, “Monofluorinated Heterocycles” (Topics in Heterocyclic Chemistry, 2012, 33–63), and presents an overview of synthetic chemistry of heterocycles with only one trifluoromethyl group directly attached to the ring (trifluoromethylated heterocycles). Particular attention is given to the modern direct trifluoromethylation methods, including catalytic reactions, organometallic reagents, carbene and hypervalent chemistry, utilization of ionic nucleophilic and electrophilic trifluoromethylating agents, and to other pertinent trends. One of the emphases of the review is compounds with biomedical potential.

Cite this article as:

Gakh A. Andrei and Shermolovich Yuriy, Trifluoromethylated Heterocycles, Current Topics in Medicinal Chemistry 2014; 14 (7) . https://dx.doi.org/10.2174/1568026614666140202210424