Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

Title:Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

Volume: 14 Issue: 7

Author(s): Gregory Landelle, Armen Panossian and Frederic R. Leroux

Affiliation:

Keywords: Fluorine, trifluoromethoxylation, trifluoromethylthiolation, drug discovery, ethers, thioethers, catalysis.

Abstract: The ever-growing number of fluorinated compounds in medicinal and agrochemical applications has led to a remarkable positive emulation in research. The last few years have been the witness of several advances in the search of more effective and user-friendlier methods for the introduction of fluorine as substituent or of fluorinated groups on various structures. In particular, the synthesis of trifluoromethyl ethers and thioethers is receiving increasing attention due to the peculiar properties of the OCF₃ and SCF₃ groups. This review will cover the different methods for the preparation of trifluoromethyl ethers and thioethers, and will emphasize on the most recent developments, including the use of catalytic methods or of methodologies for trifluoromethylation or trifluoromethanesulfanylation.

Cite this article as:

Landelle Gregory, Panossian Armen and Leroux R. Frederic, Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery, Current Topics in Medicinal Chemistry 2014; 14 (7) . https://dx.doi.org/10.2174/1568026614666140202210016