An Expedient Synthesis and Screening for Antiacetylcholinesterase Activity of Piperidine Embedded Novel Pentacyclic Cage Compounds

Title:An Expedient Synthesis and Screening for Antiacetylcholinesterase Activity of Piperidine Embedded Novel Pentacyclic Cage Compounds

Volume: 10 Issue: 2

Author(s): Raju Suresh Kumar, Abdulrahman I. Almansour, Natarajan Arumugam, Hasnah Osman, Mohamed Ashraf Ali, Alireza Basiri and Yalda Kia

Affiliation:

Keywords: Alzheimer's disease, AChE inhibitor, 1, 3-Dipolar cycloaddition, azomethine ylide, diazapentacycles and microwave irradiation.

Abstract: The aim of this study was to synthesize and evaluate diazapentacyclic analogs for their acetylcholinesterase (AChE) inhibitory activity. The pentacyclic analogs were synthesized by one-pot three-component domino reactions in a microwave synthesizer. Most of the compounds exhibited moderate to good AChE inhibitory activity, compound 5i showed potent inhibitory activity with IC₅₀ 1.12±0.01 µM and this may provide a new lead for developing potential inhibitors for Alzheimer's disease.

Cite this article as:

Kumar Suresh Raju, Almansour I. Abdulrahman, Arumugam Natarajan, Osman Hasnah, Ali Ashraf Mohamed, Basiri Alireza and Kia Yalda, An Expedient Synthesis and Screening for Antiacetylcholinesterase Activity of Piperidine Embedded Novel Pentacyclic Cage Compounds, Medicinal Chemistry 2014; 10 (2) . https://dx.doi.org/10.2174/157340641002140131170054