Abstract
Conformationally rigid phosphoric acids derived from suitably substituted axially dissymmetric 1,1’-bi-2,2’-naphthol (BINOL) find wide application in organic synthesis. These chiral Brønsted acids are able to catalyze enantioselective transformations of electrophilic imines with both carbon-centered and other hetero nucleophiles to generate enantioenriched products of academic, industrial and biological significance. Selected examples of this transformation as well as catalytic action and stereochemical features of plausible transition state intermediates are discussed in the present review.
Keywords: Imine, Nucleophile, Asymmetric Organocatalysis, Dissymmetric BINOL, Chiral Brønsted Acids, Hydrogen-Bond, Enantiomeric Excess, Synthesis.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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