New Insulin-Mimetic and Hypoglycemic Hetero-Binuclear Zinc(II)/ Oxovanadium(IV) Complex

Title:New Insulin-Mimetic and Hypoglycemic Hetero-Binuclear Zinc(II)/ Oxovanadium(IV) Complex

Volume: 4 Issue: 1

Author(s): Takayasu Moroki, Hiroyuki Yasui, Yusuke Adachi, Katsuhiko Yoshizawa, Airo Tsubura, Kazuhiko Ozutsumi, Misaki Katayama and Yutaka Yoshikawa

Affiliation:

Keywords: Antidiabetic effect, extended X-ray absorption fine structure, hetero-binuclear complex, testicular toxicity, zinc and vanadium complex.

Abstract: Over the last two decades, we have proposed several types of orally active insulin–mimetic mononuclear zinc(II) complexes based on several coordination environments. Herein, we demonstrate the hypoglycemic activity and potentially low testicular toxicity of a binuclear Zn²⁺/VO²⁺ complex of N,N'-bis(salicylidene)ethylenediamine ([(VOZn)fsaen]). The chemical structure of this complex was evaluated using an extended X-ray absorption fine structure (EXAFS) technique. The in vivo hypoglycemic effect of [(VOZn)fsaen] was evaluated using type-2-like diabetic model mice treated by daily oral administrations. The hetero-binuclear complex [(VOZn)fsaen] exhibited glucose-lowering effect without triggering morphological changes in the testes, despite the recognized potentially significant toxicity of oxovanadium(IV) (VO²⁺) complexes in the testes.

Cite this article as:

Moroki Takayasu, Yasui Hiroyuki, Adachi Yusuke, Yoshizawa Katsuhiko, Tsubura Airo, Ozutsumi Kazuhiko, Katayama Misaki and Yoshikawa Yutaka, New Insulin-Mimetic and Hypoglycemic Hetero-Binuclear Zinc(II)/ Oxovanadium(IV) Complex, Current Inorganic Chemistry (Discontinued) 2014; 4 (1) . https://dx.doi.org/10.2174/1877944104666140116210753

DOI https://dx.doi.org/10.2174/1877944104666140116210753	Print ISSN 1877-9441
Publisher Name Bentham Science Publisher	Online ISSN 1877-945X