Transition Metal Complexes of 8-Aminoquinoline-5-Substituted Uracils with Antioxidative and Cytotoxic Activities

Title:Transition Metal Complexes of 8-Aminoquinoline-5-Substituted Uracils with Antioxidative and Cytotoxic Activities

Volume: 10 Issue: 9

Author(s): Ratchanok Pingaew, Apilak Worachartcheewan, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul

Affiliation:

Keywords: Metal complex, 8-aminoquinoline, Uracils, Antioxidant, Cytotoxicity.

Abstract: Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds.

Cite this article as:

Pingaew Ratchanok, Worachartcheewan Apilak, Prachayasittikul Veda, Prachayasittikul Supaluk, Ruchirawat Somsak and Prachayasittikul Virapong, Transition Metal Complexes of 8-Aminoquinoline-5-Substituted Uracils with Antioxidative and Cytotoxic Activities, Letters in Drug Design & Discovery 2013; 10 (9) . https://dx.doi.org/10.2174/15701808113109990004

DOI https://dx.doi.org/10.2174/15701808113109990004	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X