L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems

Title:L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems

Volume: 1 Issue: 1

Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar

Affiliation:

Keywords: 2-aminobenzothiazole, 1, 4-dihydropyridines, chromenoindenopyridines, chromenoquinolines, indenoquinolines, Knoevenagel condensation, medicinally privileged heterocycles, Michael addition, multicomponent reaction, organocatalysis, L-proline, pyranoquinolines.

Abstract: Structurally diverse unsymmetrically annulated 1,4-dihydropyridines have been synthesized by L-proline catalyzed four-component domino protocol involving the reaction of 2-aminobenzothiazole, thiophene-2-carbaldehyde and carbonyl compounds in ethanol. The utilization of L-proline in the multicomponent reaction will make the present protocol attractive for synthesis of 1,4-dihydropyridines in terms of reaction efficiency, atom-economy and environmental safety.

Cite this article as:

Khandelwal Sarita, Rajawat Anshu and Kumar Mahendra, L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems, Current Organocatalysis 2014; 1 (1) . https://dx.doi.org/10.2174/22133372114016660004