Abstract
Reactive oxygen species (ROS) such as superoxide anion radical (O2-. ) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2-. homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as cancer, brain and myocardial infarction, and inflammation. Quantitative analysis of O2-. by a convenient method is a subject of intense research, since most of ROS are derived from O2-. . In situ real-time measurement of O2-. is very important to understand the relevance of ROS to many diseases. Recent progress in electrochemical sensors for the facile detection of O2-. , including biosensors utilizing a variety of metalloproteins as sensing elements for O2-. and very recently developed all-synthetic sensors with a high selectivity for O2-. detection, is reviewed. Emphasis is placed on the possibility of the all-synthetic sensor for convenient in vivo measurement of ROS.
Keywords: photodynamic therapy, DNA cleavage, BIOSENSORS, Superoxide Dismutase, Iron protoporphyrin, microelectrode
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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