Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids

Sanela      Smajilovic; Petrine      Wellendorph; Hans      Brauner-Osborne

doi:10.2174/13816128113199990576

Abstract

A number of nutrient sensing seven trans-membrane (7TM) receptors have been identified and characterized over the past few years. While the sensing mechanisms to carbohydrates and free fatty acids are well understood, the molecular basis of amino acid sensing has recently come to the limelight. The present review describes the current status of promiscuous L-α-amino acid sensors, the calcium sensing receptor (CaSR), the GPRC6A receptor, the T1R1/T1R3 receptor and also their molecular pharmacology, expression pattern and physiological significance.

Keywords: Amino acid-sensing, 7TM receptors, CaSR, GPRC6A, T1R1/T1R3.

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