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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Painting the Target Around the Arrow: Two-Step Prodrug Therapies from a Carbohydrate Chemists Perspective

Author(s): Todd A. Houston

Volume 4, Issue 4, 2007

Page: [264 - 268] Pages: 5

DOI: 10.2174/156720107782151278

Price: $65

Abstract

Selective accumulation of an exogenous enzyme or activating agent at a target cell allows use of prodrugs that will be unmasked only at this site. This can reduce the side effects of chemotherapy and allow more potent drugs to be used in various treatments. Examples of this two-step prodrug therapy include antibody- (ADEPT, ADAPT), genetic- (GDEPT, VDEPT) and macromolecule-based approaches (PDEPT, LEAPT). Carbohydrate chemistry and glycobiology feature in each of these areas and is the focus of this review.

Keywords: Abzymes, antibodies, asialoglycoprotein receptor, daunorubicin, doxorubicin, glycoconjugates, glycosidases, HPMA, prodrugs

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