Hydroarylation of Substituted Norbornene Amino Acids: Studies on Long-Range Stereo-Electronic Effects on the Regioselectivity of the Addition

Title:Hydroarylation of Substituted Norbornene Amino Acids: Studies on Long-Range Stereo-Electronic Effects on the Regioselectivity of the Addition

Volume: 16 Issue: 22

Author(s): Alessandro Ruffoni, Alessandro Casoni, Maria Luisa Gelmi, Sara Pellegrino and Francesca Clerici

Affiliation:

Keywords: Bicyclic alkenes, catalysis, hydroarylations, norbornene amino acid derivatives, Pd-catalyzed reactions, regioselectivity

Abstract: Studies on the Pd-catalyzed hydroarylation reaction of a library of differently substituted norbornene amino acid derivatives with numerous halogenoarenes are described. The effect on the regiochemistry of remote substituents, arylating agents and reaction conditions was considered. The reaction occurred with moderate to good yields and a moderate level of regioselectivity being the coupling at C-5 favorite.

Cite this article as:

Ruffoni Alessandro, Casoni Alessandro, Luisa Gelmi Maria, Pellegrino Sara and Clerici Francesca, Hydroarylation of Substituted Norbornene Amino Acids: Studies on Long-Range Stereo-Electronic Effects on the Regioselectivity of the Addition, Current Organic Chemistry 2012; 16 (22) . https://dx.doi.org/10.2174/138527212804004472