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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

New Approaches to Nitrogen Containing Heterocycles: Enantioselective Organocatalyzed Synthesis of Dihydropyridines (DHP's), Quinolizidine Derivatives and Dihydropyrimidines (DHPM's)

Author(s): Hoai T. Pham, Isabelle Chataigner and Jean-Luc Renaud

Volume 16, Issue 15, 2012

Page: [1754 - 1775] Pages: 22

DOI: 10.2174/138527212802651322

Abstract

Nitrogen-containing heterocycles, and more specifically the chiral ones, possess various biological and pharmaceutical properties. Among the approaches to these compounds, the organocatalyzed asymmetric multicomponent reaction has emerged as a powerful tool. This review will focus on the later development to chiral dihydropyridines, dihydropyrimidines and quinolizidines via asymmetric organocatalyzed synthesis....

Keywords: Dihydropyridines, Dihydropyrimidines, Quinolizidines, Chiral Brønsted acids, Chiral thioureas, Proline type derivatives, multicomponent condensation, cyclization, chiral pocket, Bronsted acids


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