Abstract
3,3’-disubstituted axially dissymmetric BINOLS, owing to their lower acidity have limited organocatalytic applications in stereoselective transformations. Nevertheless, they serve as potent and immediate precursors to much stronger Brønsted acids e.g. binaphthyl phosphoric acids. The review lists some suitably substituted and sterically demanding BINOLS, their use in organic transformations and possibility to convert them into stronger Bronsted acids as more effective organocatalysts.
Keywords: Asymmetric Organocatalysis, Dissymmetric BINOL, Chiral Phosphoric Acids, Hydrogen-Bond, Synthesis, stereoselective, nucleophile, electrophile, 1, 1’-binaphthyl-2, 2’-diols, enantioselective, allylboration
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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