Diversity-Oriented Synthesis of Functionalized Phenols by Regioselective [3+3] Cyclocondensations of 1,3-Bis(silyloxy)-1,3-butadienes with 3-Alkoxy-2-en-1-ones and Related Substrates

Title:Diversity-Oriented Synthesis of Functionalized Phenols by Regioselective [3+3] Cyclocondensations of 1,3-Bis(silyloxy)-1,3-butadienes with 3-Alkoxy-2-en-1-ones and Related Substrates

Volume: 16 Issue: 5

Author(s): Gnuni Karapetyan, Tuan T. Dang, Muhammad Sher, Tariel V. Ghochikyan, Ashot Saghyan, Peter Langer

Affiliation:

Keywords: Cyclization, Cyclocondensation, Functionalized phenols, Regioselectivity

Abstract:

Formal [3+3] cyclocondensation reactions of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with functionalized and nonfunctionalized 1-alkyl- and 1-aryl-3-alkoxy-2-en-1-ones, 1,1-dichloro-3-buten-2-ones, 3-acyl-4,5-dihydrofurans and other related 1,3- dielectrophiles provide a convenient and regioselective approach to various highly substituted, functionalized phenols which are not readily available by other methods.

Cite this article as:

Gnuni Karapetyan, Tuan T. Dang, Muhammad Sher, Tariel V. Ghochikyan, Ashot Saghyan, Peter Langer , Diversity-Oriented Synthesis of Functionalized Phenols by Regioselective [3+3] Cyclocondensations of 1,3-Bis(silyloxy)-1,3-butadienes with 3-Alkoxy-2-en-1-ones and Related Substrates, Current Organic Chemistry 2012; 16 (5) . https://dx.doi.org/10.2174/138527212799859372