Oscillatory Swelling Behavior of Hydrogels Incorporated with Ion-Exchange Nanoparticles

Title: Oscillatory Swelling Behavior of Hydrogels Incorporated with Ion-Exchange Nanoparticles

Volume: 1 Issue: 1

Author(s): Qingsheng Wang, Guanqun Wang and Zhengdong Cheng

Affiliation:

Keywords: Controlled release, hydrogels, nanoparticles, oscillation, pH-sensitive, α-Zirconium phosphate, Colloidal drug carriers, protons

Abstract: α-Zirconium phosphate (α-ZrP) ion-exchange nanoparticles, acting as a proton generator, were incorporated into pH-sensitive hydrogels, poly(acrylic acid) (PAA). The hydrogels exhibited an oscillating volume change behavior in a high pH aqueous solution with influx of Na+ ions. The observed oscillatory swelling behavior was explained by an equilibrium mechanism between reactions and diffusions. This pH-sensitive hydrogels could be utilized for controlled drug delivery that periodically releases enclosed materials without external stimuli.

Cite this article as:

Wang Qingsheng, Wang Guanqun and Cheng Zhengdong, Oscillatory Swelling Behavior of Hydrogels Incorporated with Ion-Exchange Nanoparticles, Drug Delivery Letters 2011; 1 (1) . https://dx.doi.org/10.2174/2210304x11101010058