Increase of R-/S-Methadone Enantiomer Concentration Ratio in Serum of Patients Treated with Either Nevirapine or Efavirenz

Title: Increase of R-/S-Methadone Enantiomer Concentration Ratio in Serum of Patients Treated with Either Nevirapine or Efavirenz

Volume: 2 Issue: 4

Author(s): Javier Esteban, Maria de la Cruz Pellin, Carmen Gimeno, Jose Barril, Jesus Gimenez, Eva Mora and Adolfo G. Garcia-Perez

Affiliation:

Keywords: Methadone, nevirapine, efavirenz, CYP3A4, CYP2B6, hepatitis C Virus

Abstract: An increased methadone enantiomer ratio (R/S) was associated to both nevirapine (179%, n=5) and efavirenz (36%, n=9) treatments when compared with that of controls (n=52). Additionally, in four follow-up patients, both R- and S-methadone normalized concentrations decreased (19%-93%) while R/S increased (22%-314%) following nevirapine/ efavirenz treatment. R/S decreased (42%) after non-compliance with efavirenz treatment. Therefore, the methadonemaintenance- treatment outcome should be evaluated when patients are treated with drugs which are supposed to induce CYP3A4 and CYP2B6 isoforms.

Cite this article as:

Esteban Javier, Cruz Pellin de la Maria, Gimeno Carmen, Barril Jose, Gimenez Jesus, Mora Eva and Garcia-Perez G. Adolfo, Increase of R-/S-Methadone Enantiomer Concentration Ratio in Serum of Patients Treated with Either Nevirapine or Efavirenz, Drug Metabolism Letters 2008; 2 (4) . https://dx.doi.org/10.2174/187231208786734067