Abstract
Pyridines and their derivatives with various functional groups possess diverse therapeutic and industrial importance. Malononitrile is a versatile reagent in organic chemistry and widely used in various multi-component reactions as a one component for the synthesis of diverse bioactive heterocycles. Malononitrile showed exceptional reactivity than other active methylene group containing compounds due to the presence of two electron withdrawing groups. In this review, we wish to report the MCRs for the synthesis of various functionalized pyridines in which one of the starting materials is malononitrile. The present review is focusing on reports from 2006- 2013.
Keywords: 1, 4-dihydropyridine derivatives, cyanopyridines, malononitrile, multicomponent reaction, pyridinones.
Graphical Abstract
Current Organic Chemistry
Title:Malononitrile as a Key Reagent in Multicomponent Reactions for the Synthesis of Pharmaceutically Important Pyridines
Volume: 18 Issue: 19
Author(s): Anshu Dandia, Ruby Singh and Shuchi Maheshwari
Affiliation:
Keywords: 1, 4-dihydropyridine derivatives, cyanopyridines, malononitrile, multicomponent reaction, pyridinones.
Abstract: Pyridines and their derivatives with various functional groups possess diverse therapeutic and industrial importance. Malononitrile is a versatile reagent in organic chemistry and widely used in various multi-component reactions as a one component for the synthesis of diverse bioactive heterocycles. Malononitrile showed exceptional reactivity than other active methylene group containing compounds due to the presence of two electron withdrawing groups. In this review, we wish to report the MCRs for the synthesis of various functionalized pyridines in which one of the starting materials is malononitrile. The present review is focusing on reports from 2006- 2013.
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Cite this article as:
Dandia Anshu, Singh Ruby and Maheshwari Shuchi, Malononitrile as a Key Reagent in Multicomponent Reactions for the Synthesis of Pharmaceutically Important Pyridines, Current Organic Chemistry 2014; 18 (19) . https://dx.doi.org/10.2174/138527281819141028114524
DOI https://dx.doi.org/10.2174/138527281819141028114524 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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