Synthesis, Characterisation, Anti-Microbial Activity and Docking Studies of Novel Dispiro- Oxindolopyrrolidines

Adukamparai   R.S.   Babu; Raghavachary      Raghunathan; Narayanasamy      Mathivanan; Gurusamy      Omprabhac; Devadasan      Velmurugan; Rangasamy      Raghu

doi:10.2174/2212796810802030312

Abstract

A facile synthesis and characterisation of novel dispiro-oxindolopyrrolidines is delineated. The results of the anti-microbial studies of novel dispiro-oxindolopyrrolidines are correlated with the docking calculations performed on protein S12 from 30S ribosomal subunit.

Keywords: 1,3-Dipolar cycloaddition, azomethine ylide, spiro-pyrrolidines, spiro-oxindolopyrrolidine, anti-microbial activity, 30S ribosomal subunit

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