Glucocorticoid Receptor Functions in HeLa Cells Are Perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD)

Title: Glucocorticoid Receptor Functions in HeLa Cells Are Perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD)

Volume: 1 Issue: 4

Author(s): Radim Vrzal, Jitka Ulrichova, Zdenek Dvorak and Petr Pavek

Affiliation:

Keywords: Receptors, drug-metabolizing enzymes, aryl hydrocarbon, glucocorticoid

Abstract: We used 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD) and dexamethasone (DEX) to examine their effects on aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) in HeLa cells. TCDD (5 nM), DEX (100 nM) and their combination down-regulated GR after 24 h. DEX reversed AhR mRNA increase and AhR protein decrease caused by TCDD. Since AhR-GR cross-talk occurs in cell-type and species-specific manner, the presented data may serve as the basis in the understanding of mechanisms underlying mutual interactions between AhR and GR.

Cite this article as:

Vrzal Radim, Ulrichova Jitka, Dvorak Zdenek and Pavek Petr, Glucocorticoid Receptor Functions in HeLa Cells Are Perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD), Drug Metabolism Letters 2007; 1 (4) . https://dx.doi.org/10.2174/187231207783221376