Abstract
In the past ten years, experimental observations have accumulated that annexins, forming a family of homologous Ca2+- and membrane-binding proteins and represented in mammalian tissues by 12 subfamilies, are expressed in the central nervous system (CNS). Here, they exhibit multiple functions, including the role of neuroprotective agents. It was found that annexins may be related to some CNS pathologies and disorders. In addition, in vitro, they were found to bind neurotransmitter precursors and nucleotides. The nucleotide-binding properties of annexins included GTP-induced calcium channel activity. These properties suggest that some annexin isoforms may play the role of a coupling factor between calcium homeostasis and cellular metabolism in neurons and neuroendocrine cells, especially in light of the observation that annexins participate in nucleotide-dependent processes, such as vesicular transport in neurotransmitter release, and they also interact with nucleotide-binding proteins in brain.
Current Medicinal Chemistry - Central Nervous System Agents
Title: Annexins as Neuroprotective Agents in the Central Nervous System
Volume: 2 Issue: 2
Author(s): Joanna Bandorowicz-Pikula
Affiliation:
Abstract: In the past ten years, experimental observations have accumulated that annexins, forming a family of homologous Ca2+- and membrane-binding proteins and represented in mammalian tissues by 12 subfamilies, are expressed in the central nervous system (CNS). Here, they exhibit multiple functions, including the role of neuroprotective agents. It was found that annexins may be related to some CNS pathologies and disorders. In addition, in vitro, they were found to bind neurotransmitter precursors and nucleotides. The nucleotide-binding properties of annexins included GTP-induced calcium channel activity. These properties suggest that some annexin isoforms may play the role of a coupling factor between calcium homeostasis and cellular metabolism in neurons and neuroendocrine cells, especially in light of the observation that annexins participate in nucleotide-dependent processes, such as vesicular transport in neurotransmitter release, and they also interact with nucleotide-binding proteins in brain.
Export Options
About this article
Cite this article as:
Joanna Bandorowicz-Pikula , Annexins as Neuroprotective Agents in the Central Nervous System, Current Medicinal Chemistry - Central Nervous System Agents 2002; 2 (2) . https://dx.doi.org/10.2174/1568015023358238
DOI https://dx.doi.org/10.2174/1568015023358238 |
Print ISSN 1568-0150 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6158 |
Related Articles
-
Radiolabeled RGD Peptides as Integrin alpha(v)beta3–targeted PET Tracers
Current Medicinal Chemistry Gene Therapy Approaches for the Selective Killing of Cancer Cells
Current Pharmaceutical Design Bone Regeneration and Repair
Current Stem Cell Research & Therapy Translating Mismatch Repair Mechanism into Cancer Care
Current Drug Targets Specific Cytostatic and Cytotoxic Effect of Dihydrochelerythrine in Glioblastoma Cells: Role of NF-κB/β-catenin and STAT3/IL-6 Pathways
Anti-Cancer Agents in Medicinal Chemistry Viral Vectors in Cancer Immunotherapy: Which Vector for Which Strategy?
Current Gene Therapy Editorial (Thematic Issue: Mechanisms of Cancer Stem Cell Resistance to Chemotherapy)
Current Signal Transduction Therapy Identification of Tumor Targeting Agents by Phage Display
Medicinal Chemistry Reviews - Online (Discontinued) Image-Guided Photonic Energy Deposition for Cancer Ablation and Drug Delivery
Current Medical Imaging Muscarinic Acetylcholine Receptors: New Potential Therapeutic Targets in Antinociception and in Cancer Therapy
Recent Patents on CNS Drug Discovery (Discontinued) Secondary Hypertension: The Ways of Management
Current Vascular Pharmacology Delivery of Nanoparticles for Treatment of Brain Tumor
Current Drug Metabolism Preoperative Functional Magnetic Resonance Imaging (fMRI) and Transcranial Magnetic Stimulation (TMS)
Current Medical Imaging Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome
CNS & Neurological Disorders - Drug Targets Cancer “Stemness”- Regulating MicroRNAs: Role, Mechanisms and Therapeutic Potential
Current Drug Targets Small Molecules with EGFR-TK Inhibitor Activity
Current Drug Targets Expression and Function of Angiomodulating Cytokines in Rheumatoid Arthritis and Experimental Arthritis: Important Therapeutic Targets
Current Immunology Reviews (Discontinued) Stimuli-Responsive Nanoparticles for siRNA Delivery
Current Pharmaceutical Design Recent Trends in Targeted Anticancer Prodrug and Conjugate Design
Current Medicinal Chemistry Molecular Imaging of Breast Cancer: Role of RGD Peptides
Mini-Reviews in Medicinal Chemistry