Targeted Radiosensitization in Prostate Cancer

Title:Targeted Radiosensitization in Prostate Cancer

Volume: 19 Issue: 15

Author(s): Veerander P.S. Ghotra, Albert A. Geldof and Erik H.J. Danen

Affiliation:

Keywords: Prostate cancer, radiotherapy, radiosensitization

Abstract: Radiotherapy is one of the treatment options for locally or regionally advanced prostate cancer, but radioresistance of prostate cancer cells is a practical limitation of radiotherapy. The identification of molecular targets of radioresistance in prostate cancer is important to improve therapeutic intervention. The aim of this review is to give more biological insight into some well known processes involved in radioresistance of prostate cancer especially Apoptotic pathway; DNA damage response; and NF-κB(nuclear factor kappalight- chain-enhancer of activated B cells) signaling pathway. This review integrates salient, published, research findings with underlying molecular mechanisms, preclinical efficacy, and potential clinical applications of combining radiotherapy with these molecular targeted agents for the treatment of prostate cancer.

Cite this article as:

P.S. Ghotra Veerander, A. Geldof Albert and H.J. Danen Erik, Targeted Radiosensitization in Prostate Cancer, Current Pharmaceutical Design 2013; 19 (15) . https://dx.doi.org/10.2174/1381612811319150017