Therapeutic Potential of 5-HT2C Receptor Antagonists in the Treatment of Anxiety Disorders

Title: Therapeutic Potential of 5-HT2C Receptor Antagonists in the Treatment of Anxiety Disorders

Volume: 2 Issue: 6

Author(s): Martyn D. Wood

Affiliation:

Keywords: 5-hydroxytryptamine, 5-ht, anxiety, antagonists

Abstract: Anxiety disorders are the most common psychiatric illness affecting both adults and children. Following the observation that m-chlorophenylpiperazine(mCPP) induced anxiety-like states in patients and in animal models, it was shown that in man, mCPP behaves as a functionally selective agonist at the 5-hydroxytryptamine (5-HT)2C receptor. This caused much interest in the development of antagonists at the 5-HT2C receptor for the treatment of anxiety disorders. This review examines the pre-clinical and clinical evidence for a role of the 5-HT2C receptor in anxiety and evaluates the progress of compounds that target this therapeutic approach.

Cite this article as:

Wood D. Martyn, Therapeutic Potential of 5-HT2C Receptor Antagonists in the Treatment of Anxiety Disorders, Current Drug Targets - CNS & Neurological Disorders 2003; 2 (6) . https://dx.doi.org/10.2174/1568007033482698