Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives

Title:Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives

Volume: 13 Issue: 3

Author(s): Burcu Culhaoglu, Asli Capan, Mehmet Boga, Mehmet Ozturk, Turan Ozturk and Gulacti Topcu*

Affiliation:

• Department of Pharmacognosy/ Phytochemistry, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul,Turkey

Keywords: Alzheimer's disease, anticholinesterase, antioxidant, flavonoid, flavonol, 3-hydroxyflavone.

Abstract: Background: Flavones, are a class of naturally occuring polyphenolic compounds which have 2-phenylchromen-4-one structure. Various studies showed that flavones have several pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antitumour and antiallergic. In the present study, 3-hydroxyflavones also called flavonols, posessing 4'-dialkylamino moiety were synthesized, and their antioxidant and anticholinesterase activities were investigated by comparison with unmodified 3-hydroxflavone.

Method: For investigation of antioxidant potential, radical scavenging assays (DPPH•, ABTS^+_, O₂ ^.-) were used along with CUPRAC and lipid peroxidation inhibitory assays, as well as anticholinesterase activity by Ellman method.

Results: The best results were obtained for 4'-N,N-dimethyl flavonol (1) in both antioxidant and anticholinesterase activity tests, possibly due to its least steric hinderance effect. It exhibited remarkable DPPH free radical scavenging activity (2.43±0,09 μg/mL) competing with a standard compound quercetin (2.10±0,10 μg/mL). Moreover, the other tested flavonols also showed high antioxidant activities. Compounds 5 and 6 exhibited close IC50 values to those of compound 1.

Conclusion: Antioxidant activity test results were found to be well correlated with anticholinesterase activity test results indicating possible role of antioxidant compounds in the treatment of Alzheimer’s disease.

Cite this article as:

Culhaoglu Burcu, Capan Asli, Boga Mehmet, Ozturk Mehmet, Ozturk Turan and Topcu Gulacti*, Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives, Medicinal Chemistry 2017; 13 (3) . https://dx.doi.org/10.2174/1573406412666161104121642

DOI https://dx.doi.org/10.2174/1573406412666161104121642	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638