Efficient Synthesis of Fused Pyrimidine Derivatives with Biological Activity via Aza-Wittig Reaction

Title: Efficient Synthesis of Fused Pyrimidine Derivatives with Biological Activity via Aza-Wittig Reaction

Volume: 8 Issue: 5

Author(s): Ren Qingyun, Tan Xiaosong and He Hongwu

Affiliation:

Keywords: Fused pyrimidine derivatives, synthesis, aza-Wittig reaction, pharmaceutical activity, herbicidal activity, fungicidal activity, pyrido[4,3-d]pyrimidine-4(3H)-ones, 3,4-dihydro-pyrido[4,3-d] pyrimidine-8-carbonitriles, pyrazolo[3,4-b]pyrido[4,3-d]-pyrimidine-4-ones, thieno[3',2'-5,6]pyrido [4,3-d]pyrimidin-4(3H)-ones, 1,2,3-triazolo[4,5-d]pyrimidin-7-ones, 1,2,4-triazolo[1,5-a]pyrimidin- 10(3H)-ones, thiazolo[4,5-d] pyrimidin-4(3H)-ones, pyrazolo[4',3':5,6] pyrano[2,3-d]pyrimidin-4 (3H)-ones

Abstract: Pyrimidine derivatives have played an important role in the chemistry of biological systems. This review focuses on recent work of our studies on the synthesis and biological activity of fused pyrimidine derivatives including pyrido[4,3-d]pyrimidine-4(3H)- ones; 3,4-dihydro-pyrido[4,3-d]pyrimidine-8-carbonitriles; pyrazolo[3,4-b]pyrido[4,3-d]-pyrimidine-4-ones; thieno[3,2-5,6]pyrido [4,3- d]pyrimidin-4(3H)-ones; 1,2,3-triazolo[4,5-d]pyrimidin-7-ones; 1,2,4-triazolo[1,5-a]pyrimidin-10(3H)-ones; thiazolo[4,5-d]pyrimidin- 4(3H)-ones and pyrazolo[4,3:5,6]pyrano[2,3-d]pyrimidin-4(3H)-ones. The different approaches for the syntheses of these fused pyrimidine derivatives are described and reviewed. Parts of other researchers most relevant work were also included in this review.

Cite this article as:

Qingyun Ren, Xiaosong Tan and Hongwu He, Efficient Synthesis of Fused Pyrimidine Derivatives with Biological Activity via Aza-Wittig Reaction, Current Organic Synthesis 2011; 8 (5) . https://dx.doi.org/10.2174/157017911796957366