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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

MicroRNA Expression Levels in Patients with Hashimoto Thyroiditis: A Single Centre Study

Author(s): Hale O. Yilmaz*, Alper H. Cebi, Mustafa Kocak, Halil O. Ersoz and Mevlit Ikbal

Volume 21, Issue 6, 2021

Published on: 18 September, 2020

Page: [1066 - 1072] Pages: 7

DOI: 10.2174/1871530320999200918142429

Price: $65

Abstract

Objective: To determine the circulatory miRNA expression levels in patients with Hashimoto thyroiditis (HT) at the time of diagnosis and follow-up period compared with healthy controls.

Methods: We collected blood samples from 34 patients with HT (4 males and 30 females) at the time of first diagnosis (Group P) and euthyroid period (Group E). Thirty-three healthy controls (Group H) blood samples were also included in the study. Expression levels of five different circulating miRNAs (miR-22, miR-141, miR-155, miR-375, miR-451) were evaluated using real-time polymerase chain reaction.

Results: There was a significant difference in miR-375 levels between the groups P and H. Also, for miR-451, there was a significant difference between the P and E groups. Finally, there was a moderate positive correlation between thyroid-stimulating hormone values and miR-22 expression levels for the P group.

Conclusion: miRNAs have important roles at all stages of the diseases. More studies must be performed in all thyroid diseases and autoimmune diseases, including HT.

Keywords: Circulatory miRNA, Hashimoto thyroiditis, miR-451, miR-375, miR-22, autoimmune condition.

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