Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships

Costas      Giaginis; Stamatios      Theocharis; Anna      Tsantili-Kakoulidou

doi:10.2174/138955709788922601

Abstract

The present review after providing a short overview on PPARs and their pleiotropic action focuses on the QSAR studies reported mainly for PPAR-γ agonists. The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined.

Keywords: PPAR-γ, type II Diabetes, mechanism of action, 3D-QSAR, 2D-QSAR, drug design

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