Synthesis of Novel Substituted 1,3-diarylpropenone Derivatives and their In Vitro Cytotoxic Activity

Title: Synthesis of Novel Substituted 1,3-diarylpropenone Derivatives and their In Vitro Cytotoxic Activity

Volume: 6 Issue: 5

Author(s): Yordanka Ivanova, Georgi Momekov and Ognyan Petrov

Affiliation:

Keywords: Chalcone, 2(3H)-benzoxazolone, Cytotoxicity

Abstract: The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone, N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3H)-benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3H)-benzoxazolone is synthesized and its influence on cytotoxic activity is investigated.

Cite this article as:

Ivanova Yordanka, Momekov Georgi and Petrov Ognyan, Synthesis of Novel Substituted 1,3-diarylpropenone Derivatives and their In Vitro Cytotoxic Activity, Letters in Drug Design & Discovery 2009; 6 (5) . https://dx.doi.org/10.2174/1570180810906050353

DOI https://dx.doi.org/10.2174/1570180810906050353	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X