Hsp70 Structure, Function, Regulation and Influence on Yeast Prions

Title: Hsp70 Structure, Function, Regulation and Influence on Yeast Prions

Volume: 16 Issue: 6

Author(s): Deepak Sharma and Daniel C. Masison

Affiliation:

Keywords: Hsp70, chaperone, co-chaperone, prion

Abstract: Heat shock proteins protect cells from various conditions of stress. Hsp70, the most ubiquitous and highly conserved Hsp, helps proteins adopt native conformation or regain function after misfolding. Various co-chaperones specify Hsp70 function and broaden its substrate range. We discuss Hsp70 structure and function, regulation by co-factors and influence on propagation of yeast prions.

Cite this article as:

Sharma Deepak and Masison C. Daniel, Hsp70 Structure, Function, Regulation and Influence on Yeast Prions, Protein & Peptide Letters 2009; 16 (6) . https://dx.doi.org/10.2174/092986609788490230