Abstract
Osteosarcoma is the most common type of primary bone tumor in adolescents and young adults. The dysregulation of cell cycle control and cell division often results in the aberrant growth of osteosarcoma cells. The primary proteins involved in cell cycle control and cell division include checkpoint kinases (CHKs), cyclin-dependent kinases (CDKs), polo-like kinases (PLKs) and aurora kinases (AURKs). In recent years, a large number of these protein kinase inhibitors have been identified in osteosarcoma. In this review, we highlight the current drugs being developed to target these protein kinases in osteosarcoma.
Keywords: Checkpoint kinase inhibitors, cyclin-dependent kinase inhibitors, polo-like kinase inhibitors, aurora kinase inhibitors, cell cycle, osteosarcoma.
Current Pharmaceutical Design
Title:Cell Cycle Kinases in Osteosarcoma: Potential for Therapeutic Intervention
Volume: 22 Issue: 31
Author(s): Li Cheng, Chongchong Wang and Juehua Jing
Affiliation:
Keywords: Checkpoint kinase inhibitors, cyclin-dependent kinase inhibitors, polo-like kinase inhibitors, aurora kinase inhibitors, cell cycle, osteosarcoma.
Abstract: Osteosarcoma is the most common type of primary bone tumor in adolescents and young adults. The dysregulation of cell cycle control and cell division often results in the aberrant growth of osteosarcoma cells. The primary proteins involved in cell cycle control and cell division include checkpoint kinases (CHKs), cyclin-dependent kinases (CDKs), polo-like kinases (PLKs) and aurora kinases (AURKs). In recent years, a large number of these protein kinase inhibitors have been identified in osteosarcoma. In this review, we highlight the current drugs being developed to target these protein kinases in osteosarcoma.
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Cite this article as:
Cheng Li, Wang Chongchong and Jing Juehua, Cell Cycle Kinases in Osteosarcoma: Potential for Therapeutic Intervention, Current Pharmaceutical Design 2016; 22 (31) . https://dx.doi.org/10.2174/1381612822666160512151028
DOI https://dx.doi.org/10.2174/1381612822666160512151028 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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