Diphenylpentane Skeleton as a Multi-Template for Steroid Skeleton- Recognizing Receptors/Enzymes

Title: Diphenylpentane Skeleton as a Multi-Template for Steroid Skeleton- Recognizing Receptors/Enzymes

Volume: 9 Issue: 5

Author(s): Shinnosuke Hosoda, Daisuke Matsuda, Hiroshi Tomoda and Yuichi Hashimoto

Affiliation:

Keywords: Multi-template, steroids, diphenylpentane skeleton, steroid skeleton substitute, nuclear receptor, vitamin D receptor, androgen receptor, farnesoid X receptor, 5α-reductase, HMG-CoA reductase

Abstract: As an example of a multi-template approach, we focused on the 3,3-diphenylpentane (DPP) skeleton, which has been demonstrated to act as a steroid skeleton substitute. Various ligands for nuclear receptors (NRs), including vitamin D receptor (VDR), androgen receptor (AR) and farnesoid X receptor (FXR), and inhibitors of steroid metabolismrelated enzymes, including 5α-reductase and HMG-CoA reductase (HMGR), have been efficiently created by introducing various substituents onto the DPP skeleton.

Cite this article as:

Hosoda Shinnosuke, Matsuda Daisuke, Tomoda Hiroshi and Hashimoto Yuichi, Diphenylpentane Skeleton as a Multi-Template for Steroid Skeleton- Recognizing Receptors/Enzymes, Mini-Reviews in Medicinal Chemistry 2009; 9 (5) . https://dx.doi.org/10.2174/138955709788167574