The Practical Synthesis of Double Axial Chiral Guanidines

Qun-Sheng      Guo; Da-Ming      Du

doi:10.2174/157017809787893028

Abstract

Two novel double axial chiral guanidines were designed according to the concept of double axial chirality. The practical synthetic procedures from (S)-1,1-binaphthol have been developed. The title compounds were fully characterized by NMR, MS, IR and elemental analysis or HRMS. The two chiral guanidines can be interesting catalysts for asymmetric catalysis and preliminary asymmetric catalytic activity was investigated in Henry reaction and conjugate addition.

Keywords: Guanidine, chiral catalyst, organic base, synthesis

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Letters in Organic Chemistry

Title: The Practical Synthesis of Double Axial Chiral Guanidines

Volume: 6 Issue: 3

Author(s): Qun-Sheng Guo and Da-Ming Du

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Keywords: Guanidine, chiral catalyst, organic base, synthesis

Abstract: Two novel double axial chiral guanidines were designed according to the concept of double axial chirality. The practical synthetic procedures from (S)-1,1-binaphthol have been developed. The title compounds were fully characterized by NMR, MS, IR and elemental analysis or HRMS. The two chiral guanidines can be interesting catalysts for asymmetric catalysis and preliminary asymmetric catalytic activity was investigated in Henry reaction and conjugate addition.

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Guo Qun-Sheng and Du Da-Ming, The Practical Synthesis of Double Axial Chiral Guanidines, Letters in Organic Chemistry 2009; 6 (3) . https://dx.doi.org/10.2174/157017809787893028