Abstract
Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.
Keywords: Vinylogous Mukaiyama aldol reaction, vinylketene N, O-acetal, remote stereoinduction, total synthesis, natural product, polyketide
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
26