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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Facile Synthesis of Polyhydroquinoline Derivatives via the Hantzsch Reaction Under Solvent Free-Conditions Using Potassium Dodecatungsto Cobaltate Trihydrate (K5CoW12O40.3H2O)

Author(s): Lingaiah Nagarapu, Satyender Apuri, Subhashini Gaddam, Rajashaker Bantu, Venu C. Mahankhali and Srinivas Kantevari

Volume 5, Issue 1, 2008

Page: [60 - 64] Pages: 5

DOI: 10.2174/157017808783330162

Price: $65

Abstract

A facile and efficient one-pot synthesis of polyhydroquinoline derivatives via the Hantzsch reaction using a variety of aldehydes, 5,5-dimethyl-1,3-cyclohexanedione or 1,3-cyclohexanedione, ethyl acetoacetate, and ammonium acetate in the presence of potassium dodecatungstocobaltate trihydrate [K5CoW12O40. 3H2O] as a heterogeneous catalyst in a solvent-free media at 90 °C is described herein . The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times (10-25 min.), milder conditions and the catalyst exhibited remarkable reusability.

Keywords: Potassium dodecatungstocobaltate.trihydrate, 5,5-dimethyl-1,3-cyclohexanedione, 1,3-cyclohexanedione, solventfree media, polyhydroquinoline reusability


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