Combretastatin A-4 Analogs as Anticancer Agents

Title: Combretastatin A-4 Analogs as Anticancer Agents

Volume: 7 Issue: 12

Author(s): Anurag Chaudhary, S. N. Pandeya, P. Kumar, P. P. Sharma, S. Gupta, N. Soni, K. K. Verma and G. Bhardwaj

Affiliation:

Keywords: Combretastatin A-4, antitubulin, antivascular, cytotoxicity, structure-activity relationship

Abstract: Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.

Cite this article as:

Chaudhary Anurag, Pandeya N. S., Kumar P., Sharma P. P., Gupta S., Soni N., Verma K. K. and Bhardwaj G., Combretastatin A-4 Analogs as Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2007; 7 (12) . https://dx.doi.org/10.2174/138955707782795647